Modification of Carbon Paste Electrode with Molecularly ImprintedPolyaniline for Amitriptyline Analysis by Voltammetry
Keywords:
amitriptyline, carbon paste electrode, imprinted polymer, polyaniline, voltammetryAbstract
Modification of carbon paste electrodes with molecularly imprinted polyaniline (MI-PANi) for voltammetric analysis of amitriptyline (AMT) has been studied. The polymer was synthesized from aniline as monomer, ammonium peroxodisulfate as initiator, and AMT as template with a mole ratio of 2:1:0.1 using the previously developed method. AMT was then extracted from the polymer pores using water at 60°C in order to leave a selective bonding site for AMT. The MI-PANi modified electrode was fabricated with a mass ratio of activated carbon, MIP, and paraffin of 9:4:7. The modified electrode was applied to analyze AMT standard solution using differential pulse voltammetry (DPV) technique under conditions of deposition potential of 0.6 V, deposition time of 60 s, scan rate of 25 mV/s, and pH 8. The method validity was expressed by a linearity value of 0. 9904 in the concentration range of 20 – 100 ppblower detection limit of 15.33 ppb, precision of 94.25 (99.74%), accuracy value of 75.08 (103.31%), sensitivity of 0.1222 nA/ppb. The electrode showed good selectivity to AMT in the presence of glucose equal to one-tenth of the AMT concentration, as indicated by a current deviation of 4.68%. The application of the modified electrode for AMT analysis by voltammetry showed a recovery of 99.08%.
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